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<article article-type="review-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">vuzbiochemi</journal-id><journal-title-group><journal-title xml:lang="ru">Известия вузов. Прикладная химия и биотехнология</journal-title><trans-title-group xml:lang="en"><trans-title>Proceedings of Universities. Applied Chemistry and Biotechnology</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">2227-2925</issn><issn pub-type="epub">2500-1558</issn><publisher><publisher-name>ИРНИТУ</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.21285/achb.905</article-id><article-id custom-type="edn" pub-id-type="custom">LQHTED</article-id><article-id custom-type="elpub" pub-id-type="custom">vuzbiochemi-1175</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>ФИЗИКО-ХИМИЧЕСКАЯ БИОЛОГИЯ</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>PHYSICOCHEMICAL BIOLOGY</subject></subj-group></article-categories><title-group><article-title>Каротиноиды: обзор основных биотехнологических  способов и условий получения</article-title><trans-title-group xml:lang="en"><trans-title>Carotenoids: Overview of the main methods  and conditions of their preparation</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-5220-7877</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Ядерец</surname><given-names>В. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Yaderets</surname><given-names>V. V.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Ядерец Вера Владимировна, к.б.н., заведующий лабораторией</p><p>125080, г. Москва, Волоколамское шоссе, 11</p></bio><bio xml:lang="en"><p>Vera V. Yaderets, Cand. Sci. (Biology), Head of the Laboratory</p><p>11, Volokolamskoe Rd., Moscow, 125080</p></bio><email xlink:type="simple">verayaderetz@yandex.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-6652-4136</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Карпова</surname><given-names>Н. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Karpova</surname><given-names>N. V.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Карпова Наталья Викторовна, к.б.н., научный сотрудник</p><p>125080, г. Москва, Волоколамское шоссе, 11</p></bio><bio xml:lang="en"><p>Natalya V. Karpova, Cand. Sci. (Biology), Researcher</p><p>11, Volokolamskoe Rd., Moscow, 125080</p><p>   </p></bio><email xlink:type="simple">ashatanr@mail.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-3894-0255</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Глаголева</surname><given-names>Е. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Glagoleva</surname><given-names>E. V.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Глаголева Елена Викторовна, научный сотрудник</p><p>125080, г. Москва, Волоколамское шоссе, 11</p></bio><bio xml:lang="en"><p>Elena V. Glagoleva, Researcher</p><p>11, Volokolamskoe Rd., Moscow, 125080</p><p>   </p></bio><email xlink:type="simple">glagolevaev@mail.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0009-0002-8083-4349</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Петрова</surname><given-names>К. С.</given-names></name><name name-style="western" xml:lang="en"><surname>Petrova</surname><given-names>K. S.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Петрова Ксения Сергеевна, младший научный сотрудник</p><p>125080, г. Москва, Волоколамское шоссе, 11</p></bio><bio xml:lang="en"><p>Kseniya S. Petrova, Junior Researcher</p><p>11, Volokolamskoe Rd., Moscow, 125080</p><p>   </p></bio><email xlink:type="simple">petrova.ksenia.s@yandex.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-1115-6532</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Шибаева</surname><given-names>А. С.</given-names></name><name name-style="western" xml:lang="en"><surname>Shibaeva</surname><given-names>A. S.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Шибаева Александра Сергеевна, младший научный сотрудник</p><p>125080, г. Москва, Волоколамское шоссе, 11</p></bio><bio xml:lang="en"><p>Alexandra S. Shibaeva, Junior Researcher</p><p>11, Volokolamskoe Rd., Moscow, 125080</p><p>   </p></bio><email xlink:type="simple">aleksandrashibaeva@mail.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-5161-5051</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Джавахия</surname><given-names>В. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Dzhavakhiya</surname><given-names>V. V.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Джавахия Вахтанг Витальевич, к.б.н., старший научный сотрудник</p><p>125080, г. Москва, Волоколамское шоссе, 11</p></bio><bio xml:lang="en"><p>Vahtang V. Dzhavakhiya, Cand. Sci. (Biology), Senior Researcher</p><p>11, Volokolamskoe Rd., Moscow, 125080</p><p>   </p></bio><email xlink:type="simple">vahoru@mail.ru</email><xref ref-type="aff" rid="aff-1"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru">Российский биотехнологический университет<country>Россия</country></aff><aff xml:lang="en">Russian Biotechnological University<country>Russian Federation</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2024</year></pub-date><pub-date pub-type="epub"><day>27</day><month>03</month><year>2024</year></pub-date><volume>14</volume><issue>1</issue><fpage>41</fpage><lpage>54</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Ядерец В.В., Карпова Н.В., Глаголева Е.В., Петрова К.С., Шибаева А.С., Джавахия В.В., 2024</copyright-statement><copyright-year>2024</copyright-year><copyright-holder xml:lang="ru">Ядерец В.В., Карпова Н.В., Глаголева Е.В., Петрова К.С., Шибаева А.С., Джавахия В.В.</copyright-holder><copyright-holder xml:lang="en">Yaderets V.V., Karpova N.V., Glagoleva E.V., Petrova K.S., Shibaeva A.S., Dzhavakhiya V.V.</copyright-holder><license license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://vuzbiochemi.elpub.ru/jour/article/view/1175">https://vuzbiochemi.elpub.ru/jour/article/view/1175</self-uri><abstract><p>Каротиноиды представляют собой группу изопреноидных пигментов, обладающих высокой биологической активностью, не ограниченной провитаминными свойствами. Благодаря способности участвовать в окислительно-восстановительных реакциях, каротины все чаще рассматриваются в качестве перспективных соединений в системах профилактики и коррекции сердечно-сосудистых и нейродегенеративных нарушений, онкологии и других заболеваний. Каротиноиды широко используются при изготовлении пищевых добавок и красителей, кормов для аквакультуры, сельскохозяйственных животных и птиц, а также в нутрицевтике и косметике. При составлении оптимальных рационов кормления отдельно рассматривается питательность по витамину А, поскольку данный витамин является жизненно необходимым для нормального роста, развития, поддержания и воспроизводства. Основным предшественником витамина А является β-каротин, поступающий в организм исключительно с растительными кормами. Однако содержащийся в растительном сырье каротин является неустойчивым соединением, в связи с чем становится актуальным использование кормовых добавок, содержащих в своем составе в числе прочего и β-каротин. В промышленности каротиноиды получают путем или химического, или биологического синтеза. При этом большую часть – 80–90% каротиноидов – получают путем именно химического синтеза. В то же время запрос общества на экологизацию производства диктует необходимость поиска альтернативных путей получения каротиноидов. В данной статье представлен обзор основных биотехнологических способов получения каротинов с использованием ряда микроорганизмов, включая микроводоросли, бактерии и грибы, а также проанализировано влияние условий культивирования на выход целевых пигментов. </p></abstract><trans-abstract xml:lang="en"><p>Carotenoids represent a group of isoprenoid pigments whose high biological activity is not limited to their provitamin properties. Due to their ability to participate in redox reactions, carotenes are increasingly considered as promising compounds in the prevention and correction of cardiovascular and neurodegenerative disorders, as well as in oncology and the treatment of various other diseases. Carotenoids are widely used in the manufacture </p><p>of food additives and dyes, feed for aquaculture, farm animals and poultry, as well as in so-called nutraceuticals and cosmetics. When formulating optimal feeding rations, vitamin A nutrition is often considered separately due to its vital role in normal growth, development, maintenance and reproduction. The main precursor of vitamin A is β-carotene, which naturally enters the body exclusively via vegetable-based provender. However, since the carotene contained in plant raw materials is an unstable compound, the use of feed additives containing β-carotene becomes relevant. In industry, carotenoids can be produced either by chemical or biological synthesis. However, the majority of carotenoids – 80–90% – are obtained by chemical synthesis. At the same time, public demand for sustainable production dictates the need to find alternative approaches for obtaining this valuable commodity. The article provides an overview of the main biotechnological methods for the production of carotenes using various microorganisms, including microalgae, bacteria and fungi, as well as analysing the effect of culture conditions on the yield of target pigments.</p></trans-abstract><kwd-group xml:lang="ru"><kwd>каротиноиды</kwd><kwd>микроорганизмы</kwd><kwd>биосинтез</kwd><kwd>биотехнологический способ получения</kwd><kwd>условия культивирования</kwd></kwd-group><kwd-group xml:lang="en"><kwd>carotenoids</kwd><kwd>microorganisms</kwd><kwd>biosynthesis</kwd><kwd>biotechnological production methods</kwd><kwd>culture conditions</kwd></kwd-group><funding-group xml:lang="ru"><funding-statement>Работа выполнена в рамках государственного задания Министерства науки и высшего образования Российской Федерации (тема № 123012000071-1).</funding-statement></funding-group><funding-group xml:lang="en"><funding-statement>The Ministry of Science and Higher Education of the Russian Federation supported the research (theme no. 123012000071-1).</funding-statement></funding-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Pagels F., Vasconcelos V., Guedes A.C. 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