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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">vuzbiochemi</journal-id><journal-title-group><journal-title xml:lang="ru">Известия вузов. Прикладная химия и биотехнология</journal-title><trans-title-group xml:lang="en"><trans-title>Proceedings of Universities. Applied Chemistry and Biotechnology</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">2227-2925</issn><issn pub-type="epub">2500-1558</issn><publisher><publisher-name>ИРНИТУ</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.21285/achb.973</article-id><article-id custom-type="edn" pub-id-type="custom">BXZACK</article-id><article-id custom-type="elpub" pub-id-type="custom">vuzbiochemi-1452</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>ФИЗИКО-ХИМИЧЕСКАЯ БИОЛОГИЯ</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>PHYSICOCHEMICAL BIOLOGY</subject></subj-group></article-categories><title-group><article-title>Повреждения печени и почек у мышей, вызванные ацетаминофеном: лечение корневищем Alpinia officinarum</article-title><trans-title-group xml:lang="en"><trans-title>Acetaminophen-induced liver and kidney injuries in mice: treatment with Alpinia officinarum rhizome</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0009-0004-7841-6636</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Делавар</surname><given-names>А.</given-names></name><name name-style="western" xml:lang="en"><surname>Delavar</surname><given-names>A.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Делавар Азин, магистр, ассистент, химический факультет</p><p>3149968111, г. Карадж, Бульвар Моазин, Комплекс Имама Али, Иран</p></bio><bio xml:lang="en"><p>Azin Delavar, M. Sc., Assistant, Department of Chemistry</p><p>Imam Ali Complex, Moazen Blvd., Karaj, 3149968111, Iran</p></bio><email xlink:type="simple">delavar.azi18@gmail.com</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0009-0007-9340-183X</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Шахами</surname><given-names>С.</given-names></name><name name-style="western" xml:lang="en"><surname>Shahami</surname><given-names>S.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Шахами Сомайех, магистр, ассистент, химический факультет</p><p>3149968111, г. Карадж, Бульвар Моазин, Комплекс Имама Али, Иран</p></bio><bio xml:lang="en"><p>Somayeh Shahami, M. Sc., Assistant, Department of Chemistry</p><p>Imam Ali Complex, Moazen Blvd., Karaj, 3149968111, Iran</p></bio><email xlink:type="simple">s.shahami1@gmail.com</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0009-0004-5348-080X</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Собханян</surname><given-names>А.</given-names></name><name name-style="western" xml:lang="en"><surname>Sobhanian</surname><given-names>A.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Собханян Али, д.фарм.н., доцент</p><p>1936893813, г. Тегеран, ул. доктора Шариати, Зарганде, Иран</p></bio><bio xml:lang="en"><p>Ali Sobhanian, Dr. Sci. (Pharmacy), Associate Professor, Department of Pharmaceutical Sciences</p><p>Zargandeh, Dr. Shariati St., Tehran, 1949635881, Iran</p></bio><email xlink:type="simple">s.alisobhanian@gmail.com</email><xref ref-type="aff" rid="aff-2"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-4813-2876</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Ахмади</surname><given-names>А.</given-names></name><name name-style="western" xml:lang="en"><surname>Ahmadi</surname><given-names>A.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Ахмади Аббас, д.х.н., профессор, химический факультет</p><p>3149968111, г. Карадж, Бульвар Моазин, Комплекс Имама Али, Иран</p></bio><bio xml:lang="en"><p>Abbas Ahmadi, Dr. Sci. (Chemistry), Professor, Department of Chemistry</p><p>Imam Ali Complex, Moazen Blvd., Karaj, 3149968111, Iran</p></bio><email xlink:type="simple">abbasahmadi3957@gmail.com</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-9209-8484</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Рогани</surname><given-names>М.</given-names></name><name name-style="western" xml:lang="en"><surname>Roghani</surname><given-names>M.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Рогани Мехрдад, д.м.н., профессор</p><p>3319118651, г. Тегеран, пр. Северный Каргар, 1471, Иран</p></bio><bio xml:lang="en"><p>Mehrdad Roghani, Dr. Sci. (Physiology), Professor</p><p>1471, North Kargar Ave., Tehran, 3319118651, Iran</p></bio><email xlink:type="simple">mehjour@yahoo.com</email><xref ref-type="aff" rid="aff-3"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>Исламский университет Азад, филиал в г. Карадже</institution><country>Иран</country></aff><aff xml:lang="en"><institution>Islamic Azad University</institution><country>Islamic Republic of Iran</country></aff></aff-alternatives><aff-alternatives id="aff-2"><aff xml:lang="ru"><institution>Исламский университет Азад, филиал в г. Тегеране</institution><country>Иран</country></aff><aff xml:lang="en"><institution>Islamic Azad University</institution><country>Islamic Republic of Iran</country></aff></aff-alternatives><aff-alternatives id="aff-3"><aff xml:lang="ru"><institution>Центр нейрофизиологических исследований, Университет Шахед</institution><country>Иран</country></aff><aff xml:lang="en"><institution>Neurophysiology Research Center, Shahed University</institution><country>Islamic Republic of Iran</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2025</year></pub-date><pub-date pub-type="epub"><day>31</day><month>05</month><year>2025</year></pub-date><volume>15</volume><issue>2</issue><fpage>167</fpage><lpage>177</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Делавар А., Шахами С., Собханян А., Ахмади А., Рогани М., 2025</copyright-statement><copyright-year>2025</copyright-year><copyright-holder xml:lang="ru">Делавар А., Шахами С., Собханян А., Ахмади А., Рогани М.</copyright-holder><copyright-holder xml:lang="en">Delavar A., Shahami S., Sobhanian A., Ahmadi A., Roghani M.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://vuzbiochemi.elpub.ru/jour/article/view/1452">https://vuzbiochemi.elpub.ru/jour/article/view/1452</self-uri><abstract><p>Парацетамол (ацетаминофен) широко используется во всем мире в качестве анальгетика и жаропонижающего средства. Он эффективен и безопасен при приеме в терапевтических дозах, однако его передозировка может привести к токсическому поражению печени и почек как у людей, так и у животных. Лекарственные растения являются важным компонентом в рационе питания человека, а также активно применяются в области здравоохранения, и многие из них обладают защитным эффектом от повреждений печени и почек. Данное исследование направлено на изучение защитных эффектов различных экстрактов Alpinia officinarum (галангал, I) для печени и почек у мышей, подвергшихся воздействию ацетаминофена. В частности, в ходе работы изучено влияние экстрактов, полученных с помощью различных растворителей, включая полярные, неполярные органические растворители и водные растворы. Результаты исследования показали, что эфирные масла, этанольные и хлороформенные экстракты оказывают наиболее выраженное защитное влияние на печень и почки. Это защитное влияние может быть обусловлено наличием флавоноидов, алкалоидов, терпеноидов, жирных кислот и фитостеролов в указанных экстрактах. В заключение следует отметить, что эфирное масло, этанол и хлороформ, использованные для экстракции корневища галангала, эффективно изолировали различные биоактивные компоненты, что обеспечило существенную защиту от поражения печени и почек, вызванного парацетамолом у мышей.</p></abstract><trans-abstract xml:lang="en"><p>Paracetamol (acetaminophen) is widely used around the world as both an analgesic and antipyretic medication. It is effective and safe when taken in therapeutic doses; however, overdosing can result in liver and kidney toxicity in both humans as well as animals. Medicinal plants are important sources of nutrition and healthcare for humans, and many of them have demonstrated protective effects against liver and kidney injuries. This research investigates the liver and kidney protective effects of various Alpinia officinarum (galangal, I) extracts in mice exposed to acetaminophen. Specifically, it examines the effects of extracts obtained using different solvents, including polar and nonpolar organic solvents and aqueous solutions. The study’s findings indicated that essential oil, hydroethanolic, and chloroform extracts have the most significant protective effects on the liver and kidney. These protective effects may attributed to the presence of flavonoids, alkaloids, terpenoids, fatty acids, and phytosterols in these extracts. In conclusion, essential oil, hydroethanol, and chloroform used for the extraction of galangal rhizome effectively isolated various bioactive components, which provided substantial protection against the liver and kidney injuries caused by paracetamol in mice.</p></trans-abstract><kwd-group xml:lang="ru"><kwd>парацетамол</kwd><kwd>Alpinia officinarum (галангал)</kwd><kwd>заболевания печени и почек</kwd><kwd>лекарственные растения</kwd><kwd>полярные и неполярные растворители</kwd></kwd-group><kwd-group xml:lang="en"><kwd>paracetamol</kwd><kwd>Alpinia officinarum (Galangal)</kwd><kwd>liver and kidney injuries</kwd><kwd>medicinal plants</kwd><kwd>polar and nonpolar extracts</kwd></kwd-group><funding-group><funding-statement xml:lang="ru">Статья является частью исследовательского проекта Исламского университета Азад (филиал в г. Карадже), за который авторы хотели бы выразить искреннюю благодарность. Также авторы выражают признательность г-ну Моджтабе Чайчи, внештатному инструктору ESL, EFL, EAL, ESP и IELTS, за помощь в написании статьи.</funding-statement><funding-statement xml:lang="en">This article was a research project at Islamic Azad University, Karaj Branch, for which the authors would rather voice their sincere gratitude to them. Also, the authors appreciate Mr. Mojtaba Chaichi, the freelance ESL, EFL, EAL, ESP, and IELTS instructor, for the article.</funding-statement></funding-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Kaplowitz N. Drug-induced liver disorders: implications for drug development and regulation. Drug Safety. 2001;24:483-490. DOI: 10.2165/00002018-200124070-00001.</mixed-citation><mixed-citation xml:lang="en">Kaplowitz N. Drug-induced liver disorders: implications for drug development and regulation. Drug Safety. 2001;24:483-490. 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