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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">vuzbiochemi</journal-id><journal-title-group><journal-title xml:lang="ru">Известия вузов. Прикладная химия и биотехнология</journal-title><trans-title-group xml:lang="en"><trans-title>Proceedings of Universities. Applied Chemistry and Biotechnology</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">2227-2925</issn><issn pub-type="epub">2500-1558</issn><publisher><publisher-name>ИРНИТУ</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.21285/2227-2925-2022-12-1-38-49</article-id><article-id custom-type="elpub" pub-id-type="custom">vuzbiochemi-751</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>ФИЗИКО-ХИМИЧЕСКАЯ БИОЛОГИЯ</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>PHYSICOCHEMICAL BIOLOGY</subject></subj-group></article-categories><title-group><article-title>Самоагрегирующие свойства инулина в разбавленном растворе</article-title><trans-title-group xml:lang="en"><trans-title>Self-aggregating properties of inulin in a dilute solution</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-9897-2451</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Насриддинов</surname><given-names>А. C.</given-names></name><name name-style="western" xml:lang="en"><surname>Nasriddinov</surname><given-names>A. S.</given-names></name></name-alternatives><bio xml:lang="ru"><p>А. С. Насриддинов, к.х.н., докторант734065, г. Душанбе, ул. Айни, 299/2</p></bio><bio xml:lang="en"><p>Abubakr S. Nasriddinov, Cand. Sci. (Chemistry), Doctoral Student,V. I. Nikitin Institute of Chemistry</p><p>299/2, Aini St., 734063, Dushanbe</p></bio><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-4881-6944</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Ашуров</surname><given-names>А. И.</given-names></name><name name-style="western" xml:lang="en"><surname>Ashurov</surname><given-names>A. I.</given-names></name></name-alternatives><bio xml:lang="ru"><p>А. И. Ашуров, научный сотрудник</p><p>734065, г. Душанбе, ул. Айни, 299/2</p></bio><bio xml:lang="en"><p>Ashurboi I. Ashurov, Researcher, V. I. Nikitin Institute of Chemistry,</p><p>299/2, Aini St., 734063, Dushanbe</p></bio><email xlink:type="simple">ashurboy_1593@mail.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0001-5601-3255</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Холов</surname><given-names>Ш. Ё.</given-names></name><name name-style="western" xml:lang="en"><surname>Kholov</surname><given-names>Sh. E.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Ш. Ё. Холов, к.т.н., ведущий научный сотрудник лаборатории химии высокомолекулярных соединений</p><p>734065, г. Душанбе, ул. Айни, 299/2</p></bio><bio xml:lang="en"><p>Shavkat E. Kholov, Cand. Sci. (Engineering), Leading Researcher,V. I. Nikitin Institute of Chemistry</p><p>299/2, Aini St., 734063, Dushanb</p></bio><email xlink:type="simple">shavkat.kholov@yandex.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-4068-0739</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Исмоилов</surname><given-names>И. Б.</given-names></name><name name-style="western" xml:lang="en"><surname>Ismoilov</surname><given-names>I. B.</given-names></name></name-alternatives><bio xml:lang="ru"><p>И. Б. Исмоилов, соискатель кандидатской степенипри лаборатории химии высокомолекулярныхсоединений</p><p>734065, г. Душанбе, ул. Айни, 299/2</p></bio><bio xml:lang="en"><p>Ikromdzhon B. Ismоilov, Researcher, V. I. Nikitin Institute of Chemistry299/2, Aini St., 734063, Dushanb</p></bio><email xlink:type="simple">ikromjon.bomurodi92@mail.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0003-4254-7699</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Усманова</surname><given-names>С. Р.</given-names></name><name name-style="western" xml:lang="en"><surname>Usmanova</surname><given-names>S. R.</given-names></name></name-alternatives><bio xml:lang="ru"><p>С. Р. Усманова, к.х.н., ведущий научный сотрудник лаборатории химии высокомолекулярных соединений,</p><p>734065, г. Душанбе, ул. Айни, 299/2</p></bio><bio xml:lang="en"><p>Surae R. Usmanova, Cand. Sci. (Chemistry), Leading Researcher,V. I. Nikitin Institute of Chemistry</p><p>299/2, Aini St., 734063, Dushanbe</p></bio><email xlink:type="simple">surayo.usmanova@gmail.com</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-0023-2229</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Мухидинов</surname><given-names>З. К.</given-names></name><name name-style="western" xml:lang="en"><surname>Mukhidinov</surname><given-names>Z. K.</given-names></name></name-alternatives><bio xml:lang="ru"><p>З. К. Мухидинов, д.х.н., профессор, главный научный сотрудник лаборатории химии высокомолекулярныхсоединений734065, г. Душанбе, ул. Айни, 299/2</p></bio><bio xml:lang="en"><p>Zainiddin K. Mukhidinov, Dr. Sci. (Chemistry), Professor,Chief Researcher, V. I. Nikitin Institute of Chemistry299/2, Aini St., 734063, Dushanbe</p></bio><email xlink:type="simple">zainy@mail.ru</email><xref ref-type="aff" rid="aff-1"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>Институт химии им. В. И. Никитина Национальной академии наук Республики Таджикистан</institution><country>Таджикистан</country></aff><aff xml:lang="en"><institution>V. I. Nikitin Institute of Chemistry, National Academy of Sciences of the Republic of Tajikistan</institution><country>Tajikistan</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2022</year></pub-date><pub-date pub-type="epub"><day>01</day><month>04</month><year>2022</year></pub-date><volume>12</volume><issue>1</issue><fpage>38</fpage><lpage>49</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Насриддинов А.C., Ашуров А.И., Холов Ш.Ё., Исмоилов И.Б., Усманова С.Р., Мухидинов З.К., 2022</copyright-statement><copyright-year>2022</copyright-year><copyright-holder xml:lang="ru">Насриддинов А.C., Ашуров А.И., Холов Ш.Ё., Исмоилов И.Б., Усманова С.Р., Мухидинов З.К.</copyright-holder><copyright-holder xml:lang="en">Nasriddinov A.S., Ashurov A.I., Kholov S.E., Ismoilov I.B., Usmanova S.R., Mukhidinov Z.K.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://vuzbiochemi.elpub.ru/jour/article/view/751">https://vuzbiochemi.elpub.ru/jour/article/view/751</self-uri><abstract><p>Создание функциональных пищевых продуктов на основе инулинсодержащего растительного сырья позволит обеспечить население функциональным питанием диабетического характера. В связи с этим обоснование технологических параметров процесса получения инулина из клубней топинамбура (Helianthus tuberosus L.) путем определения его количественных характеристик является актуальным. В данной работе с целью обоснования технологических параметров процесса получения инулина из клубней топинамбура флэш-экстракционным и традиционным методами были установлены его качественные характеристики, а именно гидродинамические свойства и молекулярная масса в растворе. Результаты гидродинамических свойств и молекулярной массы образцов инулина топинамбура, полученные флэш-экстракционным методом при высокой температуре 105 °С за короткое и более длительное время, традиционным методом при температуре 75 °С в нейтральной среде, продемонстрировали самоагрегирующие свойства этого биополимера. Инулин, экстрагированный флэш-экстракционным способом, состоит из двух фракций: низкомолекулярного инулина и высокомолекулярного агрегата, который представляет собой комплекс полисахарида. Эти агрегаты могут формироваться как межмолекулярными, так и внутримолекулярными взаимодействиями различных фракций инулина в растворе. Как и следовало ожидать, их разделение невозможно обычными методами, при концентрировании на УФ-мембране формировался ряд субфракций, образовывалось большое количество агрегированного не растворимого в воде микрогеля. В то время как инулин, полученный традиционным способом, состоит из одной фракции, но имеет высокую степень полидисперсности. Показано, что для получения качественного инулина, предназначенного для пищевых и профилактических целей, предпочтительно использовать флэш-метод экстракции за короткое время.</p></abstract><trans-abstract xml:lang="en"><p>The creation of functional food products based on inulin-containing vegetable raw materials can provide the population with functional diabetic nutrition. In this regard, investigation of the technological parameters of obtaining inulin from Jerusalem artichoke tubers (Helianthus tuberosus L.) and determination of its quantitative characteristics seem highly relevant. This study aims to determine the qualitative characteristics of inulin obtained from Jerusalem artichoke tubers by both flash extraction and conventional methods. Jerusalem artichoke inulin samples were obtained by the flash extraction method at a high temperature of 105 °C during both shorter and longer periods of time and by the conventional method at a temperature of 75 °C in a neutral medium. The hydrodynamic properties and molecular weight of the samples demonstrated the self-aggregating properties of this biopolymer. Inulin obtained by the flash extraction method consists of two fractions: low-molecular weight inulin and high-molecular weight aggregate represented by a polysaccharide complex. These aggregates can be formed both by inter- and intramolecular interactions of various inulin fractions in the solution. As expected, their isolation using conventional methods appeared impossible: the method of concentration yielded a number of subfractions on the UV membrane and a large amount of aggregated water-insoluble microgel. At the same time, inulin obtained by the conventional method consists of one fraction, although having a high degree of polydispersity. In order to obtain high-quality inulin intended for nutritional and prophylactic purposes, it is preferable to use the flash extraction method over short periods of time.</p></trans-abstract><kwd-group xml:lang="ru"><kwd>топинамбур</kwd><kwd>инулин</kwd><kwd>флэш-экстракция</kwd><kwd>молекулярная масса</kwd><kwd>конформация</kwd><kwd>агрегация</kwd></kwd-group><kwd-group xml:lang="en"><kwd>Jerusalem artichoke</kwd><kwd>inulin</kwd><kwd>flash extraction</kwd><kwd>molecular weight</kwd><kwd>conformation</kwd><kwd>aggregation</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Anderson-Dekkers I., Nouwens-Roest M., Brigitte P., Vaughan E. Inulin. In: Handbook of Hydrocolloids. Third ed. Chapter 17. Amsterdam: Woodhead Publishing Series in Food Science, Technology and Nutrition, 2021. P. 537–562. https://doi.org/10.1016/B978-0-12-820104-6.00015-2.</mixed-citation><mixed-citation xml:lang="en">Anderson-Dekkers I., Nouwens-Roest M., Brigitte P., Vaughan E. Inulin. In: Handbook of Hydrocolloids. Third ed. Chapter 17. Amsterdam: Woodhead Publishing Series in Food Science, Technology and Nutrition; 2021, p. 537-562. https://doi.org/10. 1016/B978-0-12-820104-6.00015-2.</mixed-citation></citation-alternatives></ref><ref id="cit2"><label>2</label><citation-alternatives><mixed-citation xml:lang="ru">Kontogiorgos V. Stabilisers. Inulin. In: Encyclopedia of Dairy Sciences. Third ed. NY: Academic Press, 2022. Vol. 2. P. 689–694. https://doi.org/10.1016/B978-0-12-818766-1.00321-4.</mixed-citation><mixed-citation xml:lang="en">Kontogiorgos V. Stabilisers. Inulin. In: Encyclopedia of Dairy Sciences. Third ed. NY: Academic Press; 2022, vol. 2, p. 689-694. https://doi.org/10.10 16/B978-0-12-818766-1.00321-4.</mixed-citation></citation-alternatives></ref><ref id="cit3"><label>3</label><citation-alternatives><mixed-citation xml:lang="ru">BeMiller J. N. Inulin and Konjac Glucomannan. In: Carbohydrate Chemistry for Food Scientists. Amsterdam: Elsevier Inc., AACC International, 2019. P. 253–259. https://doi.org/10.1016/B978-0-12-812069-9.00010-8.</mixed-citation><mixed-citation xml:lang="en">BeMiller J. N. Inulin and Konjac Glucomannan. In: Carbohydrate Chemistry for Food Scientists. Amsterdam: Elsevier Inc., AACC International; 2019, p. 253-259. https://doi.org/10.1016/B978-0- 12-812069-9.00010-8.</mixed-citation></citation-alternatives></ref><ref id="cit4"><label>4</label><citation-alternatives><mixed-citation xml:lang="ru">Kozhukhova M. A., Nazarenko M. N., Barkhatova T. V., Khripko I. A. Obtaining and identification of inulin from Jerusalem artichoke (Helianthus tuberosus) tubers // Foods and Raw Materials. 2015. Vol. 3, no. 2. P. 13–22. https://doi.org/10.12737/13115.</mixed-citation><mixed-citation xml:lang="en">Kozhukhova M. A., Nazarenko M. N., Barkhatova T. V., Khripko I. A. Obtaining and identification of inulin from Jerusalem artichoke (Helianthus tuberosus) tubers. Foods and Raw Materials. 2015;3(2):13-22. https://doi.org/10.12737/13115.</mixed-citation></citation-alternatives></ref><ref id="cit5"><label>5</label><citation-alternatives><mixed-citation xml:lang="ru">Chiavaro E., Vittadini E., Corradini C. Physicochemical characterization and stability of inulin gels // European Food Research and Technology. 2007. Vol. 225. P. 85–94. https://doi.org/10.1007/s00217-006-0385-y.</mixed-citation><mixed-citation xml:lang="en">Chiavaro E., Vittadini E., Corradini C. Physicochemical characterization and stability of inulin gels. European Food Research and Technology. 2007; 225:85-94. https://doi.org/10.1007/s00217-006-0385-y.</mixed-citation></citation-alternatives></ref><ref id="cit6"><label>6</label><citation-alternatives><mixed-citation xml:lang="ru">Mensink M. A., Frijlink H. W., van der Voort Maarschalk K., Hinrichs W. L. J. Inulin, a flexible oligosaccharide I: Review of its physicochemical characteristics // Carbohydrate Polymers. 2015. Vol. 130. P. 405–419. https://doi.org/10.1016/j.carbpol.2015.05.026.</mixed-citation><mixed-citation xml:lang="en">Mensink M. A., Frijlink H. W., van der Voort Maarschalk K., Hinrichs W. L. J. Inulin, a flexible oligosaccharide I: Review of its physicochemical characteristics. Carbohydrate Polymers. 2015;130:405-419. https://doi.org/10.1016/j.carbpol.2015.05.026.</mixed-citation></citation-alternatives></ref><ref id="cit7"><label>7</label><citation-alternatives><mixed-citation xml:lang="ru">Mudgil D., Barak S. Classification, Technological Properties, and Sustainable Sources. In: Dietary Fiber: Properties, Recovery, and Applications. Chapter 2. NY: Academic Press, 2019. P. 27–58. https://doi.org/10.1016/B978-0-12-816495-2.00002-2.</mixed-citation><mixed-citation xml:lang="en">Mudgil D., Barak S. Classification, Technological Properties, and Sustainable Sources. In: Dietary Fiber: Properties, Recovery, and Applications. Chapter 2. NY: Academic Press; 2019, p. 27-58. https://doi.org/ 10.1016/B978-0-12-816495-2.00002-2.</mixed-citation></citation-alternatives></ref><ref id="cit8"><label>8</label><citation-alternatives><mixed-citation xml:lang="ru">Манукян Л. С., Кочикян В. Т., Андреасян Н. А., Афян К. Б., Балаян А. М. Выделение инулина из различного растительного сырья // Биологический журнал Армении. 2014. N 4. С. 71–75.</mixed-citation><mixed-citation xml:lang="en">Manukyan L. S., Kochikyan V. T., Andreasyan N. A., Afyan K. B., Balayan A. M. Isolation of inulin from various plant materials. Biologicheskii zhurnal Armenii. 2014;(4):71-75. (In Russian).</mixed-citation></citation-alternatives></ref><ref id="cit9"><label>9</label><citation-alternatives><mixed-citation xml:lang="ru">Ma X. Y., Zhang L. H., Shao H. B., Xu G., Zhang F., Ni F. T., et al. Jerusalem artichoke (Helianthus tuberosus), a medicinal salt-resistant plant has high adaptability and multiple-use values // Journal of Medicinal Plants Research. 2011. Vol. 5, no. 8. P. 1272–1279.</mixed-citation><mixed-citation xml:lang="en">Ma X. Y., Zhang L. H., Shao H. B., Xu G., Zhang F., Ni F. T., et al. Jerusalem artichoke (Helianthus tuberosus), a medicinal salt-resistant plant has high adaptability and multiple-use values. Journal of Medicinal Plants Research. 2011;5(8):1272-1279.</mixed-citation></citation-alternatives></ref><ref id="cit10"><label>10</label><citation-alternatives><mixed-citation xml:lang="ru">Ашуров А. И., Джонмуродов А. С., Мухидинов З. К., Усманова С. Р., Партоев К. Интенсификация процесса получения полисахаридов из корнеклубней топинамбура // Вестник Таджикского национального университета. Серия естественных наук. 2019. N 3. C. 208–214.</mixed-citation><mixed-citation xml:lang="en">Ashurov A. I., Dzhonmurodov A. S., Mukhidinov Z. K., Usmanova S. R., Partoev K. The intensification of the process for the polysaccharides extraction from Jerusalem artichoke. Vestnik Tadzhikskogo natsional'nogo universiteta. Seriya estestvennykh nauk = Bulletin of the Tajik National University. Series of natural sciences. 2019;3:208- 214. (In Russian).</mixed-citation></citation-alternatives></ref><ref id="cit11"><label>11</label><citation-alternatives><mixed-citation xml:lang="ru">Shoaib M., Shehzada A., Omarc M., Rakha A., Raza H., Sharif H. R., et al. Inulin: properties, health benefits, and food applications // Carbohydrate Polymers. 2016. Vol. 147. P. 444–454. https://doi.org/10.1016/j.carbpol.2016.04.020.</mixed-citation><mixed-citation xml:lang="en">Shoaib M., Shehzada A., Omarc M., Rakha A., Raza H., Sharif H. R., et al. Inulin: properties, health benefits, and food applications. Carbohydrate Polymers. 2016;147:444-454. https://doi.org/10.1016/j. carbpol.2016.04.020.</mixed-citation></citation-alternatives></ref><ref id="cit12"><label>12</label><citation-alternatives><mixed-citation xml:lang="ru">Colwell J. A. Type II diabetes, pre-diabetes, and the metabolic syndrome // The Journal of the American Medical Association. 2011. Vol. 306, no. 2. P. 215–238. https://doi.org/10.1001/jama.2011.970.</mixed-citation><mixed-citation xml:lang="en">Colwell J. A. Type II diabetes, pre-diabetes, and the metabolic syndrome. The Journal of the American Medical Association. 2011;306(2):215- 238. https://doi.org/10.1001/jama.2011.970.</mixed-citation></citation-alternatives></ref><ref id="cit13"><label>13</label><citation-alternatives><mixed-citation xml:lang="ru">Jackson P. P. J., Wijeyesekera A., Theis S., Harsselaar J., Rastall R. A. Food for thought! Inulintype fructans: does the food matrix matter? // Journal of Functional Foods. 2022. Vol. 90. P. 104987. https://doi.org/10.1016/j.jff.2022.104987.</mixed-citation><mixed-citation xml:lang="en">Jackson P. P. J., Wijeyesekera A., Theis S., Harsselaar J., Rastall R. A. Food for thought! Inulintype fructans: does the food matrix matter? Journal of Functional Foods. 2022;90:104987. https://doi. org/10.1016/j.jff.2022.104987.</mixed-citation></citation-alternatives></ref><ref id="cit14"><label>14</label><citation-alternatives><mixed-citation xml:lang="ru">Шаненко Е. Ф., Силаева М. А., Ермолаева Г. А. Топинамбур – сырье профилактического питания // Вопросы питания. 2016. Т. 85. N S2. С. 219.</mixed-citation><mixed-citation xml:lang="en">Shanenko E. F., Silaeva M. A., Ermolaeva G. A. Jerusalem artichoke – raw materials for preventive nutrition. Voprosy pitaniya = Problems of Nutrition. 2016;85(S2):219. (In Russian).</mixed-citation></citation-alternatives></ref><ref id="cit15"><label>15</label><citation-alternatives><mixed-citation xml:lang="ru">Amjadi S., Almasi H., Hamishehkar H., Khaledabad M. A., Lim L.-T. Cationic inulin as a new surface decoration hydrocolloid for improving the stability of liposomal nanocarriers // Colloids and Surfaces B: Biointerfaces. 2022. Vol. 213. P. 112401. https://doi.org/10.1016/j.colsurfb.2022.112401.</mixed-citation><mixed-citation xml:lang="en">Amjadi S., Almasi H., Hamishehkar H., Khaledabad M. A., Lim L.-T. Cationic inulin as a new surface decoration hydrocolloid for improving the stability of liposomal nanocarriers. Colloids and Surfaces B: Biointerfaces. 2022;213:112401. https://doi. org/10.1016/j.colsurfb.2022.112401.</mixed-citation></citation-alternatives></ref><ref id="cit16"><label>16</label><citation-alternatives><mixed-citation xml:lang="ru">Franck A. Technological functionality of inulin and oligofructose // British Journal of Nutrition. 2002. Vol. 87, no. S2. P. 287–291. https://doi.org/10.1079/BJN/2002550.</mixed-citation><mixed-citation xml:lang="en">Franck A. Technological functionality of inulin and oligofructose. British Journal of Nutrition. 2002;87 (S2):287-291. https://doi.org/10.1079/BJN/2002550.</mixed-citation></citation-alternatives></ref><ref id="cit17"><label>17</label><citation-alternatives><mixed-citation xml:lang="ru">Barclay T., Ginic-Markovic M., Cooper P., Petrovsky N. Inulin – a versatile polysaccharide with multiple pharmaceutical and food chemical uses // Journal of Excipients and Food Chemicals. 2010. Vol. 1, no. 3. P. 27–50.</mixed-citation><mixed-citation xml:lang="en">Barclay T., Ginic-Markovic M., Cooper P., Petrovsky N. Inulin – a versatile polysaccharide with multiple pharmaceutical and food chemical uses. Journal of Excipients and Food Chemicals. 2010;1(3):27-50.</mixed-citation></citation-alternatives></ref><ref id="cit18"><label>18</label><citation-alternatives><mixed-citation xml:lang="ru">Ronkart S. N., Deroanne C., Paquot M., Fougnies C., Blecker C. S. Impact of the crystallization pathway of inulin on its mono-hydrate to hemihydrate thermal transition // Food Chemistry. 2010. Vol. 119, no. 1. P. 317–322. https://doi.org/10.1016/j.foodchem.2009.06.035.</mixed-citation><mixed-citation xml:lang="en">Ronkart S. N., Deroanne C., Paquot M., Fougnies C., Blecker C. S. Impact of the crystallization pathway of inulin on its mono-hydrate to hemihydrate thermal transition. Food Chemistry. 2010; 119(1):317-322. https://doi.org/10.1016/j.foodchem. 2009.06.035.</mixed-citation></citation-alternatives></ref><ref id="cit19"><label>19</label><citation-alternatives><mixed-citation xml:lang="ru">Dan A., Ghosh S., Moulik S. P. Physicochemical studies on the biopolymer inulin: a critical evaluation of its self-aggregation, aggregationmorphology, interaction with water, and thermal stability // Biopolymers. 2009. Vol. 91, no. 9. P. 687– 699. https://doi.org/:10.1002/bip.21199.</mixed-citation><mixed-citation xml:lang="en">Dan A., Ghosh S., Moulik S. P. Physicochemical studies on the biopolymer inulin: a critical evaluation of its self-aggregation, aggregationmorphology, interaction with water, and thermal stability. Biopolymers. 2009;91(9):687-699. https://doi. org/:10.1002/bip.21199.</mixed-citation></citation-alternatives></ref><ref id="cit20"><label>20</label><citation-alternatives><mixed-citation xml:lang="ru">Muhidinov Z. K., Teshaev Kh., Jonmurodov A., Khalikov D., Fishman M. Physico-chemical characterization of pectic polysaccharides from various sources obtained by steam assisted flash extraction (SAFE) // Macromolecular Symposia. 2012. Vol. 317-318, no. 1. P. 142–148. https://doi.org/10.1002/masy.201100108.</mixed-citation><mixed-citation xml:lang="en">Muhidinov Z. K., Teshaev Kh., Jonmurodov A., Khalikov D., Fishman M. Physico-chemical characterization of pectic polysaccharides from various sources obtained by steam assisted flash extraction (SAFE). Macromolecular Symposia. 2012;317-318(1):142-148. https://doi.org/10.1002/masy.201100108.</mixed-citation></citation-alternatives></ref><ref id="cit21"><label>21</label><citation-alternatives><mixed-citation xml:lang="ru">Muhidinov Z. K., Bobokalonov J. T., Ismoilov I. B., Strahan G. D., Chau H. K., Hotchkiss A. T., et al. Characterization of two types of polysaccharides from Eremurus hissaricus roots growing in Tajikistan // Food Hydrocolloids. 2020. Vol. 105. P. 105768. https://doi.org/10.1016/j.foodhyd.2020.105768.</mixed-citation><mixed-citation xml:lang="en">Muhidinov Z. K., Bobokalonov J. T., Ismoilov I. B., Strahan G. D., Chau H. K., Hotchkiss A. T., et al. Characterization of two types of polysaccharides from Eremurus hissaricus roots growing in Tajikistan. Food Hydrocolloids. 2020;105:105768. https:// doi.org/10.1016/j.foodhyd.2020.105768.</mixed-citation></citation-alternatives></ref><ref id="cit22"><label>22</label><citation-alternatives><mixed-citation xml:lang="ru">Li W., Zhang J., Yu C., Li Q., Dong F., Wang G., et al. Extraction, degree of polymerization determination and prebiotic effect evaluation of inulin from Jerusalem artichoke // Carbohydrate Polymers. 2015. Vol. 121. P. 315–319. https://doi.org/10.1016/j.carbpol.2014.12.055. 2</mixed-citation><mixed-citation xml:lang="en">Li W., Zhang J., Yu C., Li Q., Dong F., Wang G., et al. Extraction, degree of polymerization determination and prebiotic effect evaluation of inulin from Jerusalem artichoke. Carbohydrate Polymers. 2015;121:315-319. https://doi.org/10.1016/j.carbpol.2014.12.055.</mixed-citation></citation-alternatives></ref><ref id="cit23"><label>23</label><citation-alternatives><mixed-citation xml:lang="ru">Lo ́pez-Molina D., Navarro-Mart ́ınez M. D., Melgarejo F. R., Hiner A. N. P., Chazarra S., Rodríguez-López J. N. Molecular properties and prebiotic effect of inulin obtained from artichoke(Cynara scolymus L.) // Phytochemistry. 2005. Vol. 66, no. 12. P. 1476–1484. https://doi.org/10.1016/j.phytochem.2005.04.003.</mixed-citation><mixed-citation xml:lang="en">Lo ́pez-Molina D., Navarro-Mart ́ınez M. D., Melgarejo F. R., Hiner A. N. P., Chazarra S., Rodríguez-López J. N. Molecular properties and prebiotic effect of inulin obtained from artichoke (Cynara scolymus L.). Phytochemistry. 2005;66 (12):1476-1484. https://doi.org/10.1016/j.phytochem. 2005. 04.003.</mixed-citation></citation-alternatives></ref><ref id="cit24"><label>24</label><citation-alternatives><mixed-citation xml:lang="ru">Kitamura S., Hirano T., Takeo K., Mimura M., Kajiwara K., Stokke B. T., et al. Conformation of (2→1)-β-d-fructan in aqueous solution // International Journal of Biological Macromolecules. 1994. Vol. 16, no. 6. P. 313–317. https://doi.org/10.1016/0141-8130(94)90062-0.</mixed-citation><mixed-citation xml:lang="en">Kitamura S., Hirano T., Takeo K., Mimura M., Kajiwara K., Stokke B. T., et al. Conformation of (2→1)-β-d-fructan in aqueous solution. International Journal of Biological Macromolecules. 1994;16(6):313- 317. https://doi.org/10.1016/0141-8130(94)90062-0.</mixed-citation></citation-alternatives></ref><ref id="cit25"><label>25</label><citation-alternatives><mixed-citation xml:lang="ru">Wolff D., Czapla S., Heyer A. G., Radosta S., Mischnick P., Springer J. Globular shape of high molar mass inulin revealed by static light scattering and viscometry // Polymer. 2000. Vol. 41, no. 22. P. 8009–8016. https://doi.org/10.1016/S0032-3861(00)00168-3.</mixed-citation><mixed-citation xml:lang="en">Wolff D., Czapla S., Heyer A. G., Radosta S., Mischnick P., Springer J. Globular shape of high molar mass inulin revealed by static light scattering and viscometry. Polymer. 2000;41(22):8009-8016. https://doi.org/10.1016/S0032-3861(00)00168-3.</mixed-citation></citation-alternatives></ref><ref id="cit26"><label>26</label><citation-alternatives><mixed-citation xml:lang="ru">Podzimek S. Light scattering, size exclusion chromatography and asymmetric flow field flow fractionation powerful tools for the characterization of polymers, protein and nanoparticles. New Jersey: Hoboken Publisher, 2011. P. 333. https://doi.org/10.1002/9780470877975.</mixed-citation><mixed-citation xml:lang="en">Podzimek S. Light scattering, size exclusion chromatography and asymmetric flow field flow fractionation powerful tools for the characterization of polymers, protein and nanoparticles. New Jersey: Hoboken Publisher; 2011, p. 333. https://doi.org/ 10.1002/9780470877975.</mixed-citation></citation-alternatives></ref><ref id="cit27"><label>27</label><citation-alternatives><mixed-citation xml:lang="ru">French A. D. Accessible conformations of the B-D-(2–1)-and-(2–6)-linked D-fructans inulin and levan // Carbohydrate Research. 1988. Vol. 176, no. 1. P. 17–30.</mixed-citation><mixed-citation xml:lang="en">French A. D. Accessible conformations of the B-D-(2–1)-and-(2–6)-linked D-fructans inulin and levan. Carbohydrate Research. 1988;176(1):17-30.</mixed-citation></citation-alternatives></ref><ref id="cit28"><label>28</label><citation-alternatives><mixed-citation xml:lang="ru">Vereyken I. J., van Kuik J. A., Evers T. H., Rijken P. J., de Kruijff B. Structural requirements of the fructan–lipid interaction // Biophysical Journal. 2003. Vol. 84, no. 5. P. 3147–3154. https://doi.org/ 10.1016/s0006-3495(03)70039-3.</mixed-citation><mixed-citation xml:lang="en">Vereyken I. J., van Kuik J. A., Evers T. H., Rijken P. J., de Kruijff B. Structural requirements of the fructan–lipid interaction. Biophysical Journal. 2003;84(5):3147-3154. https://doi.org/10.1016/s0006- 3495(03)70039-3.</mixed-citation></citation-alternatives></ref><ref id="cit29"><label>29</label><citation-alternatives><mixed-citation xml:lang="ru">Timmermans J. W., Slaghek T. M., Iizuka M., Van den Ende W., De Roover J., van Laere A. Isolation and structural analysis of new fructans produced by chicory // Journal of Carbohydrate Chemistry. 2001. Vol. 20, no. 5. P. 375–395. https://doi.org/10.1081/CAR-100105711.</mixed-citation><mixed-citation xml:lang="en">Timmermans J. W., Slaghek T. M., Iizuka M., Van den Ende W., De Roover J., van Laere A. Isolation and structural analysis of new fructans produced by chicory. Journal of Carbohydrate Chemistry. 2001; 20(5):375-395. https://doi.org/10.1081/CAR-100105711</mixed-citation></citation-alternatives></ref></ref-list><fn-group><fn fn-type="conflict"><p>The authors declare that there are no conflicts of interest present.</p></fn></fn-group></back></article>
