vuzbiochemiИзвестия вузов. Прикладная химия и биотехнологияProceedings of Universities. Applied Chemistry and Biotechnology2227-29252500-1558ИРНИТУ10.21285/2227-2925-2022-12-2-231-237vuzbiochemi-808Research ArticleФИЗИКО-ХИМИЧЕСКАЯ БИОЛОГИЯPHYSICOCHEMICAL BIOLOGYОбзор фитохимических и некоторых исследований биологической активности Leptopyrum fumarioides (L.) ReichenbReview of phytochemical and some biological activity of Leptopyrum fumarioides (L.) Reichenb.https://orcid.org/0000-0002-0292-0279СолонгоА.SolongoA.

А. Солонго, к.х.н., старший научный сотрудник

13330, г. Улан-Батор, пр-т Мира, корп. 4

Amgalan Solongo, PhD (Chemistry), Senior Researcher

4, Peace Ave., 13330, Ulaanbaatar

solongoa@mas.ac.mnhttps://orcid.org/0000-0002-5252-2615ДончеваЦ.DonchevaT.

Ц. Дончева, к.х.н., доцент, старший научный сотрудник

1113, г. София, пр-т акад. Георгия Бончева, 4

Tsvetelina Doncheva, PhD (Chemistry), Associated Professor, Senior Researcher

4, Acad. Georgy Bonchev Ave., 1113, Sofia

Tsvetelina.Doncheva@orgchm.bas.bghttps://orcid.org/0000-0001-8095-0345ДэлгэрбатБ.DelgerbatB.

Б. Дэлгэрбат, к.б.н., научный сотрудник14230, г. Улан-Батор, ул. Юнеско, 31

Boldbaatar Delgerbat, PhD (Biology), Researcher

31, Unesco St., 14230, Ulaanbaatar

b.delgerbat@onomfoundation.orghttps://orcid.org/0000-0002-3449-2088СэлэнгэД.SelengeD.

Д. Сэлэнгэ, к.х.н., ведущий исследователь, лауреат13330, г. Улан-Батор, пр-т Мира, корп. 4

Dangaa Selenge, PhD (Chemistry), Leading Researcher, State prize of Mongolia winner

4, Peace Ave., 13330, Ulaanbaatar

selengedangaa@gmail.comИнститут химии и химической технологии Монгольской академии наукМонголияInstitute of Chemistry and Chemical Technology, Mongolian Academy of SciencesMongoliaИнститут органической химии с центром фитохимии Болгарской академии наукБолгарияInstitute of Organic Chemistry with Centre of PhytochemistryBulgariaЦентр печени, башня ДалайМонголияThe Liver Center, Dalai TowerMongolia202204072022122231237Copyright © Солонго А., Дончева Ц., Дэлгэрбат Б., Сэлэнгэ Д., 20222022Солонго А., Дончева Ц., Дэлгэрбат Б., Сэлэнгэ Д.Solongo A., Doncheva T., Delgerbat B., Selenge D.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://vuzbiochemi.elpub.ru/jour/article/view/808

Фитохимическое изучение Leptopyrum fumaroides началось в 2011 году, с тех пор с помощью ГХ-МС было определено 14 летучих соединений, а также выделены и идентифицированы 7 флавоноидов и 4 алкалоида, 2 из которых были новыми природными соединениями. Строение природных продуктов определено и установлено методами МС-, ИК-, 1D ЯМР- и 2D ЯМРспектроскопии. Новые алкалоиды получили названия лептопирин (3) и лептофумарин (4). Лептопирин (3) представляет собой новый тип димерного бензилизохинолина и простого изохинолинового алкалоида с иминным азотом. Лептофумарин (4) является первым примером алкалоида апорфина и бензилизохинолина с двумя эфирными мостиками, которые имеют связи «голова к голове» и «хвост к хвосту». Исследованы антиоксидантная, антимутагенная, антипролиферативная, гепатопротекторная, иммуномодулирующая и противораковая активность различных экстрактов Leptopyrum fumaroides и некоторых выделенных чистых соединений. В данном обзоре наглядно показано, что фитохимическое и биологическое изучение этого вида растений только начинается и требует более детального и всестороннего изучения.

The phytochemical study of Leptopyrum fumarioides started in 2011 and since then 14 volatile compounds have been identified by GC-MS. 7 flavonoids and 4 alkaloids have been isolated and 2 of them have been recognized as new natural compounds. The structures of the natural products have been determined and ascertained by MS, as well as IR, 1D NMR and 2D NMR spectroscopic methods. The antioxidant, antimutagenic, antiproliferative, hepatoprotective, immunomodulatory, and anticancer activity of Leptopyrum fumarioides extracts and some isolated pure compounds were examined. The new alkaloids leptopyrine (3) and leptofumarine (4) were identified. Leptopyrine (3) is a new type of dimer alkaloid of benzylisoquinoline and simple isoquinoline with imine nitrogen. Leptofumarine (4) is the first example of aporphine and benzylisoquinoline alkaloid with two ether bridges which have head-to-head and tail-to-tail coupling. This review clearly shows that the phytochemical study of plant species is just beginning and requires more detailed and comprehensive study.

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The authors declare that there are no conflicts of interest present.