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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">vuzbiochemi</journal-id><journal-title-group><journal-title xml:lang="ru">Известия вузов. Прикладная химия и биотехнология</journal-title><trans-title-group xml:lang="en"><trans-title>Proceedings of Universities. Applied Chemistry and Biotechnology</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">2227-2925</issn><issn pub-type="epub">2500-1558</issn><publisher><publisher-name>ИРНИТУ</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.21285/2227-2925-2023-13-1-77-87</article-id><article-id custom-type="elpub" pub-id-type="custom">vuzbiochemi-962</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>ФИЗИКО-ХИМИЧЕСКАЯ БИОЛОГИЯ</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>PHYSICOCHEMICAL BIOLOGY</subject></subj-group></article-categories><title-group><article-title>Специализированная липидная композиция для профилактики гиперлипидемии и ожирения</article-title><trans-title-group xml:lang="en"><trans-title>Lipid compositions for the prevention of hyperlipidemia and obesity</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0001-5658-5069</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Табакаев</surname><given-names>А. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Tabakaev</surname><given-names>A. V.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Табакаев Антон Вадимович – кандидат технических наук, доцент Департамента пищевых наук и технологий, ДВФУ; младший научный сотрудник, НИИЭМ им. Г.П. Сомова.</p><p>690091, Владивосток, ул. Мордовцева, 12; 690087, Владивосток, ул. Сельская, 1</p></bio><bio xml:lang="en"><p>Anton V. Tabakaev - Cand. Sci. (Engineering), Associate Professor, Far Eastern Federal University; Junior Researcher, G.P. Somov Research Institute of Epidemiology and Microbiology.</p><p>12, Mordovtsev St., Vladivostok, 690091; 1, Sel'skaya St., Vladivostok, 690087</p></bio><email xlink:type="simple">tabakaev92@mail.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-7068-911X</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Табакаева</surname><given-names>О. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Tabakaeva</surname><given-names>O. V.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Табакаева Оксана Вацлавовна – доктор технических наук, доцент, профессор Департамента пищевых наук и технологий,</p><p>690091, Владивосток, ул. Мордовцева, 12</p></bio><bio xml:lang="en"><p>Oksana V. Tabakaeva - Dr. Sci. (Engineering), Associate Professor, Professor, Far Eastern Federal University.12, Mordovtsev St., Vladivostok, 690091</p></bio><email xlink:type="simple">yankovskaya68@mail.ru</email><xref ref-type="aff" rid="aff-2"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0001-8610-7623</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Щелканов</surname><given-names>М. Ю.</given-names></name><name name-style="western" xml:lang="en"><surname>Shchelkanov</surname><given-names>M. Yu.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Щелканов Михаил Юрьевич – доктор биологических наук, доцент, заведующий базовой кафедрой эпидемиологии, микробиологии и паразитологии, ДВФУ; директор, НИИЭМ им. Г.П. Сомова</p><p>690091, Владивосток, ул. Мордовцева, 12; 690087, Владивосток, ул. Сельская, 1</p></bio><bio xml:lang="en"><p>Mikhail Yu. Shchelkanov - Dr. Sci. (Biology), Associate Professor, Head of Basic Department of Epidemiology, Microbiology and Parasitology, Far Eastern Federal University; Director, G.P. Somov Research Institute of Epidemiology and Microbiology.</p><p>12, Mordovtsev St., Vladivostok, 690091; 1, Sel'skaya St., Vladivostok, 690087</p></bio><email xlink:type="simple">adorob@mail.ru</email><xref ref-type="aff" rid="aff-1"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>Дальневосточный федеральный университет; Научно-исследовательский институт эпидемиологии и микробиологии им. Г.П. Сомова</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Far Eastern Federal University; G.P. Somov Research Institute of Epidemiology and Microbiology</institution><country>Russian Federation</country></aff></aff-alternatives><aff-alternatives id="aff-2"><aff xml:lang="ru"><institution>Дальневосточный федеральный университет</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Far Eastern Federal University</institution><country>Russian Federation</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2023</year></pub-date><pub-date pub-type="epub"><day>05</day><month>04</month><year>2023</year></pub-date><volume>13</volume><issue>1</issue><fpage>77</fpage><lpage>87</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Табакаев А.В., Табакаева О.В., Щелканов М.Ю., 2023</copyright-statement><copyright-year>2023</copyright-year><copyright-holder xml:lang="ru">Табакаев А.В., Табакаева О.В., Щелканов М.Ю.</copyright-holder><copyright-holder xml:lang="en">Tabakaev A.V., Tabakaeva O.V., Shchelkanov M.Y.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://vuzbiochemi.elpub.ru/jour/article/view/962">https://vuzbiochemi.elpub.ru/jour/article/view/962</self-uri><abstract><p>В современном мире алиментарно-зависимые социально значимые заболевания, в частности ожирение и гиперлипидемия, приобрели масштабы эпидемии, требующей значительных усилий и средств для снижения потерь. Более эффективным и целесообразным является профилактика данных заболеваний, в том числе и с применением специализированных липидных композиций. Цель представленного исследования заключалась в разработке специализированных липидных композиций для профилактики гиперлипидемии и ожирения. Используемый метод - купажирование растительных масел и стабилизация природным антиоксидантом с целью повышения устойчивости при хранении. Жирнокислотный состав специализированных липидных композиций для профилактики гиперлипидемии и ожирения исследован методом газожидкостной хроматографии, органолептические, физико-химические показатели определены стандартными методами. Устойчивость при хранении оценивалась по перекисному и кислотному числам. В качестве компонентов использованы соевое, низкоэруковое рапсовое, льняное и рыжиковое масла, а также масло микроводорослей Schizochytrium sp. Антиоксидантом служил масляный экстракт ксантофиллов из бурой морской водоросли Дальневосточного региона - Sargassum miyabei. Специализированные липидные композиции на основе соевого масла характеризуются более высоким содержанием полиненасыщенных жирных кислот, чем на основе низкоэрукового рапсового (72,93-76,25% против 60,71-66,64%). По органолептическим и физико-химическим показателям разработанные специализированные липидные композиции для профилактики гиперлипидемии и ожирения соответствовали требованиям нормативной документации. Введение в состав специализированных липидных композиций масляного экстракта ксантофиллов из бурой водоросли Sargassum miyabei позволило существенно увеличить стабильность в хранении (6 месяцев вместо 3 месяцев контроля).</p></abstract><trans-abstract xml:lang="en"><p>Today, alimentary-associated socially significant diseases, such as hyperlipidemia and obesity, have reached epidemic proportions, thus requiring significant healthcare resources to combat the consequences. Prevention of these diseases, including by using specialized lipid compositions, seems to be a more effective and feasible approach. In this work, specialized lipid compositions for the prevention of hyperlipidemia and obesity are developed. The research was based on blending vegetable oils followed by stabilization with a natural antioxidant to increase the shelf life. The fatty acid composition of the obtained lipid compositions for the prevention of hyperlipidemia and obesity was studied by gas-liquid chromatography; the organoleptic, physical, and chemical parameters were determined by conventional methods. The shelf life was evaluated by peroxide and acid number. Soybean, low-erucic rapeseed, linseed, and camelina oils, as well as Schizochytrium sp. microalgae oil, were used. An oil extract of xanthophylls from Sargassum miyabei - a brown alga from the Far East region - was used as an antioxidant. The lipid compositions based on soybean oil were characterized by a higher content of polyunsaturated fatty acids compared to those based on low-erucic rapeseed oil (72.93-76.25% vs. 60.71-66.64%). In terms of organoleptic and physicochemical parameters, the developed lipid compositions for the prevention of hyperlipidemia and obesity meet the requirements of regulatory documentation. The introduction of an oil extract of xanthophylls from the Sargassum miyabei brown alga significantly increased the shelf life of the studied compositions (6 months compared to 3 months of control).</p></trans-abstract><kwd-group xml:lang="ru"><kwd>специализированная липидная композиция</kwd><kwd>омега-6/омега-3 жирные кислоты</kwd><kwd>ксантофиллы</kwd><kwd>ожирение</kwd><kwd>гиперлипидемия</kwd><kwd>профилактика</kwd></kwd-group><kwd-group xml:lang="en"><kwd>specialized lipid composition</kwd><kwd>omega-6/omega-3 fatty acids</kwd><kwd>xanthophylls</kwd><kwd>obesity</kwd><kwd>hyperlipidemia</kwd><kwd>prevention</kwd></kwd-group><funding-group><funding-statement xml:lang="ru">Работа выполнена при поддержке гранта РНФ (проект 22-76-00008).</funding-statement><funding-statement xml:lang="en">The work was supported by a grant from the Russian Science Foundation (project 22-76-00008).</funding-statement></funding-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Kelly T., Yang W., Chen C.S., Reynolds K., He J. 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