Synthetic components of hydrogels in tissue engineering
https://doi.org/10.21285/achb.987
EDN: CCBZMQ
Abstract
The study aims to provide an analytical review of synthetic components, such as polyethylene glycol and acrylic acid, used in the production of hydrogels, identify their advantages and disadvantages, and explore the potential applications of these materials in tissue engineering. Hydrogels constitute cross-linked three-dimensional polymers that, due to the presence of hydrophilic particles, are capable of absorbing large amounts of liquid. The physicochemical properties of hydrogels are adjusted depending on the task and are determined by the composition, component concentration, cross-linking methods and density, manufacturing methods, and the presence of additives. Hydrogels are used in various fields, including biomedicine, biotechnology, and bioengineering. It is known that components for the manufacture of hydrogels can be divided into natural, synthetic, and semi-synthetic. Unlike hydrogels prepared from natural components, synthetic hydrogels have the advantage of high reproducibility. Synthetic hydrogels offer greater flexibility in terms of chemical composition and mechanical properties, which can be adapted for specific applications by incorporating functional groups, and their transport properties can be modified by adjusting the length and density of polymer chains. Synthetic polymers have now become an important alternative in the preparation of hydrogel scaffolds, as they can be molecularly adjusted, taking into account the structure, molecular weight, mechanical strength, and biodegradability. The present article provides basic information about hydrogels, describes their structure and classification, and discusses the main synthetic components for hydrogel compositions and ways to use them.
About the Authors
N. N. Dremina
Irkutsk Scientific Center of Surgery and Traumatology
Russian Federation
Russian Federation
Natalya N. Dremina, Cand. Sci. (Biology), Senior Researcher
6, Bortsov Revolyutsii St., Irkutsk, 664003
I. S. Trukhan
Irkutsk Scientific Center of Surgery and Traumatology
Russian Federation
Russian Federation
Irina S. Trukhan, Cand. Sci. (Biology), Senior Researcher
6, Bortsov Revolyutsii St., Irkutsk, 664003
I. A. Shurygina
Irkutsk Scientific Center of Surgery and Traumatology
Russian Federation
Russian Federation
Irina A. Shurygina, Dr. Sci. (Medicine), Professor of the Russian Academy of Sciences, Deputy Director for Research
6, Bortsov Revolyutsii St., Irkutsk, 664003
M. G. Shurygin
Irkutsk Scientific Center of Surgery and Traumatology
Russian Federation
Russian Federation
Michael G. Shurygin, Dr. Sci. (Medicine), Head of Research and Laboratory Department
6, Bortsov Revolyutsii St., Irkutsk, 664003
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Review
For citations:
Dremina N.N., Trukhan I.S., Shurygina I.A., Shurygin M.G. Synthetic components of hydrogels in tissue engineering. Proceedings of Universities. Applied Chemistry and Biotechnology. (In Russ.) https://doi.org/10.21285/achb.987. EDN: CCBZMQ
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