Protective activities of some bioactive components from Salvia officinalis extracts and essential oil in acetaminophen-induced model of acute liver and kidney injury in mice
https://doi.org/10.21285/achb.1002
EDN: UTMCYY
Abstract
Drugs and toxic compounds-induced liver and kidney injuries are mostly responsible for hepatic and renal dysfunction. Many treatments have recently been proposed for these injuries, like chemicals and traditional medicines. Thus, looking for new classes of natural and safe compounds is a global demand. The genus Salvia from the Lamiaceae family are well-studied and vastly used in traditional medicine. The plant contains a variety of secondary metabolites, like terpenoids, which have shown many pharmacological activities. Based on the various reported pharmacological effectiveness of Salvia officinalis L. (sage, I), the protective effects of some extracts and essential oil of this plant by the number of polar and nonpolar organic as well as aqueous solvents on the liver and kidney injury in acetaminophen-induced mice investigated in this research. The results showed that chloroformic and carbon tetrachloride extracts of Salvia officinalis had the best effects for protecting against kidney injury, while for liver, chloroformic, ethanolic, and hydroethanolic extracts also had such effects. It can be concluded that extraction of Salvia officinalis with polar and nonpolar organic and aqueous solvents could separate various bioactive components which appropriately and remarkably improve some serum markers following acetaminophen-induced liver and kidney damage in mice.
Keywords
liver and kidney injuries,
acetaminophen-induced model,
traditional medicine,
Salvia officinalis (sage),
polar and nonpolar extracts
Supporting agencies: This article was a research project at Islamic Azad University, Karaj branch.
About the Authors
S. A. Sobhanian
TeMS.C., Islamic Azad University
Islamic Republic of Iran
Islamic Republic of Iran
Seyed Ali Sobhanian, Dr. Sci. (Pharmacy), Associate Professor, Department of Medicinal Chemistry
Zargandeh, Dr. Shariati St., Tehran, 1949635881, Iran
A. Ahmadi
Ka.C., Islamic Azad University
Islamic Republic of Iran
Islamic Republic of Iran
Abbas Ahmadi, Dr. Sci. (Chemistry), Professor, Department of Chemistry
Amir al-Momenin Complex, Esteghlal Blvd., Karaj, 3149968111, Iran
M. Roghani
Neurophysiology Research Center, Shahed University
Islamic Republic of Iran
Islamic Republic of Iran
Mehrdad Roghani, Dr. Sci. (Physiology), Professor
1471, North Kargar Ave., Tehran, 3319118651, Iran
P. Hassanlo
Ka.C., Islamic Azad University
Islamic Republic of Iran
Islamic Republic of Iran
Parinaz Hassanlo, M. Sc., Assistant, Department of Chemistry
Amir al-Momenin Complex, Esteghlal Blvd., Karaj, 3149968111, Iran
Sh. Khamoushi
Ka.C., Islamic Azad University
Islamic Republic of Iran
Islamic Republic of Iran
Shima Khamoushi, M. Sc., Assistant, Department of Chemistry
Amir al-Momenin Complex, Esteghlal Blvd., Karaj, 3149968111, Iran
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Review
For citations:
Sobhanian S.A., Ahmadi A., Roghani M., Hassanlo P., Khamoushi Sh. Protective activities of some bioactive components from Salvia officinalis extracts and essential oil in acetaminophen-induced model of acute liver and kidney injury in mice. Proceedings of Universities. Applied Chemistry and Biotechnology. https://doi.org/10.21285/achb.1002. EDN: UTMCYY
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