Synthesis and study of oligohexamethyleneguanidine hydroiodide as a radiopaque substance
https://doi.org/10.21285/2227-2925-2021-11-3-491-496
Abstract
Abstract: Diagnosis of complex injuries, such as splinter fractures and wounds, skull injuries accompanied by internal injuries that are inaccessible to visual control, presents the greatest difficulties during X-ray examination. Therefore, it is relevant to develop a drug that can help localize the site of a pathological lesion with high accuracy, relying only on the results of an X-ray study, which is possible when a reference point (substance) is applied to the patient’s skin. A radiopaque contrast compound based on an iodinated polymeric matrix with iodine as the contrasting component and polyguanidine as the carrier has been proposed to be used as a reference point substance. The choice of this class of polymers stemmed from the fact that a positive charge is localized to a greater extent on the carbon atom of the guanidine group, which allows loading iodine anions into it. Protonation of pure guanidine with hydroiodic acid has helped obtain guanidine hydroiodide. This finding was confirmed by IR spectroscopy methods (a decrease in the intensity of bands in the region of 1,380, 880 cm−1 in comparison with guanidine, as well as broadening of the band of stretching vibrations of amino groups characteristic of guanidine salts) and X-ray phase analysis. Polyhexamethylene guanidine hydroiodide was synthesized based on hexamethylenediamine and iodine-containing guanidine salt using melt polycondensation. The results show that the aqueous solutions of samples under study absorb X-radiation and are the X-ray-positive substances (exposure radiation dosage E = 0.04 mSV).
Supporting agencies: The study was carried out with the financial support of the State assignment of the Baikal Institute of Nature Management SB RAS no. 0273-2021-0007.
About the Authors
O. S. Ochirov
Baikal Institute of Nature Management SB RAS
Russian Federation
Russian Federation
Oleg S. Ochirov, Cand. Sci. (Pharmacy), Lead Engineer, Laboratory of Polymer Science
6, Sahyanova St., Ulan-Ude, 670047
S. A. Stelmakh
Baikal Institute of Nature Management SB RAS
Russian Federation
Russian Federation
Sergey A. Stelmakh, Cand. Sci. (Chemistry), Senior Researcher, laboratory of Polymer Science
6, Sahyanova St., Ulan-Ude, 670047
M. N. Grigor’eva
Baikal Institute of Nature Management SB RAS
Russian Federation
Russian Federation
Maria N. Grigor’eva, Cand. Sci. (Chemistry), Lead Engineer, Laboratory of Polymer Science
6, Sahyanova St., Ulan-Ude, 670047
V. O. Okladnikova
Baikal Institute of Nature Management SB RAS
Russian Federation
Russian Federation
Valeria O. Okladnikova, Engineer, Laboratory of Polymer Science
6, Sahyanova St., Ulan-Ude, 670047
D. M. Mognonov
Baikal Institute of Nature Management SB RAS
Russian Federation
Russian Federation
Dmitrii M. Mognonov, Dr. Sci. (Chemistry), Professor
6, Sahyanova St., Ulan-Ude, 670047
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Review
For citations:
Ochirov O.S., Stelmakh S.A., Grigor’eva M.N., Okladnikova V.O., Mognonov D.M. Synthesis and study of oligohexamethyleneguanidine hydroiodide as a radiopaque substance. Proceedings of Universities. Applied Chemistry and Biotechnology. 2021;11(3):491-496. (In Russ.) https://doi.org/10.21285/2227-2925-2021-11-3-491-496
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