PHOTODESTRUCTIVE TRANSFORMATIONS OF BENZOIC ACID AND ITS DERIVATIVES
https://doi.org/10.21285/2227-2925-2017-7-4-16-23
Abstract
The destruction kinetics of benzoic acid and its two derivative pharmaceutical preparations, furosemide and repaglinide, were studied in UV irradiated aqueous solution. The photodestruction of these preparations in the presence of hydrogen peroxide vari-ous concentrations was also studied. Out of all the studied rea-gents, the active substance of furosemide, 5-aminosulfonyl-4-chloro-2- (2-furanylmethyl) aminobenzoic acid was found to be the most susceptible to photodestruction. Conversely, repaglinide is highly resistant to photolysis, while the introduction of hydrogen peroxide slightly increases the destructive efficiency. The UV-irradiation method can be used to destroy some medications based on benzoic acid derivatives.
About the Authors
M. N. Ustinova
Belgorod State National Research University
Russian Federation
Russian Federation
O. E. Lebedeva
Belgorod State National Research University
Russian Federation
Russian Federation
V. I. Kurdupova
Belgorod State National Research University
Russian Federation
Russian Federation
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Review
For citations:
Ustinova M.N., Lebedeva O.E., Kurdupova V.I. PHOTODESTRUCTIVE TRANSFORMATIONS OF BENZOIC ACID AND ITS DERIVATIVES. Proceedings of Universities. Applied Chemistry and Biotechnology. 2017;7(4):16-23. (In Russ.) https://doi.org/10.21285/2227-2925-2017-7-4-16-23
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