Review of phytochemical and some biological activity of Leptopyrum fumarioides (L.) Reichenb.
https://doi.org/10.21285/2227-2925-2022-12-2-231-237
Abstract
The phytochemical study of Leptopyrum fumarioides started in 2011 and since then 14 volatile compounds have been identified by GC-MS. 7 flavonoids and 4 alkaloids have been isolated and 2 of them have been recognized as new natural compounds. The structures of the natural products have been determined and ascertained by MS, as well as IR, 1D NMR and 2D NMR spectroscopic methods. The antioxidant, antimutagenic, antiproliferative, hepatoprotective, immunomodulatory, and anticancer activity of Leptopyrum fumarioides extracts and some isolated pure compounds were examined. The new alkaloids leptopyrine (3) and leptofumarine (4) were identified. Leptopyrine (3) is a new type of dimer alkaloid of benzylisoquinoline and simple isoquinoline with imine nitrogen. Leptofumarine (4) is the first example of aporphine and benzylisoquinoline alkaloid with two ether bridges which have head-to-head and tail-to-tail coupling. This review clearly shows that the phytochemical study of plant species is just beginning and requires more detailed and comprehensive study.
About the Authors
A. Solongo
Institute of Chemistry and Chemical Technology, Mongolian Academy of Sciences
Mongolia
Mongolia
Amgalan Solongo, PhD (Chemistry), Senior Researcher
4, Peace Ave., 13330, Ulaanbaatar
T. Doncheva
Institute of Organic Chemistry with Centre of Phytochemistry
Bulgaria
Bulgaria
Tsvetelina Doncheva, PhD (Chemistry), Associated Professor, Senior Researcher
4, Acad. Georgy Bonchev Ave., 1113, Sofia
B. Delgerbat
The Liver Center, Dalai Tower
Mongolia
Mongolia
Boldbaatar Delgerbat, PhD (Biology), Researcher
31, Unesco St., 14230, Ulaanbaatar
D. Selenge
Institute of Chemistry and Chemical Technology, Mongolian Academy of Sciences
Mongolia
Mongolia
Dangaa Selenge, PhD (Chemistry), Leading Researcher, State prize of Mongolia winner
4, Peace Ave., 13330, Ulaanbaatar
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Review
For citations:
Solongo A., Doncheva T., Delgerbat B., Selenge D. Review of phytochemical and some biological activity of Leptopyrum fumarioides (L.) Reichenb. Proceedings of Universities. Applied Chemistry and Biotechnology. 2022;12(2):231-237. https://doi.org/10.21285/2227-2925-2022-12-2-231-237
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