PROCESS OF OBTAINING HYDROCHLORIDES OF IMMATES OF 3-PHENOXYBENZOIC ACID ON THE PINNER REACTION OPTIMIZATION

Abstract

In the framework of work on optimization of the process for the preparation of 3-phenoxybenzoic acid imidates hydrochlorides by the Pinner reaction, the effect of excess alcohol and temperature on the reaction rate and product yield was studied. It was found that the optimal process conditions are the following: the ratio of reagents: 3-phenoxybenzonitrile: alcohol = 1: 2 ÷ 3, temperature range 15-40⁰C with continuous supply of hydrogen chloride. It is proved that under these conditions there is no formation of by-products. An effective method for the preparation of 3-phenoxybenzoic acid imidate hydrochlorides has been developed, an optimal design of a periodic reactor has been proposed, which ensures a high process speed and the yield of the obtained hydrochlorides of imidates of 3-phenoxybenzoic acid of at least 95%. The authors developed a principle technological scheme that provides optimal conditions for the process and the maximum yield of the targeted products. The hydrochlorides of imidates of 3-phenoxybenzoic acid are biologically active substances, which explains the interest in finding the optimal parameters for the synthesis process, namely, reducing the reaction time and increasing the yield of the desired product.