SYNTHESIS OF 2-METHOXY-3-ARYL(HETARYL)PROPENALS BY ALDOL CONDENSATION UNDER MICROWAVE IRRADIATION
https://doi.org/10.21285/2227-2925-2017-7-4-9-15
Abstract
The developed method of synthesis of 2-methoxy-3-aryl(hetaryl)propanola by organocatalysis the cross-aldol condensation of aromatic or heteroaromatic aldehydes with matosiuk-sonnym aldehyde under microwave activation. In the syntheses were used the microwave reactor Anton Paar Monowave-300. Effective organocatalysts selected pyrrolidine (30-100 mol%), commonly used in fine organic synthesis. Advantages of this method are the absence of toxic solvents, short reaction time (1-3 min), a simple treatment of the reaction mixture. However, the yields of target products remain moderate (47-53%). Obtained new representatives of a,b unsaturated aldehydes - 2-methoxy-3-phenylpropenal and 2-methoxy-3-(2-furyl)propenal - promising objects for further studies. For example, these compounds may be of interest as starting reagents in the synthesis of heterocyclic compounds (pyrroles, oxazolidines, pyrazoles, imidazolidine,. etc.).
About the Authors
N. V. Vchislo
A.E. Favorsky Irkutsk Institute of Chemistry SB RAS
Russian Federation
Russian Federation
E. A. Verochkina
A.E. Favorsky Irkutsk Institute of Chemistry SB RAS
Russian Federation
Russian Federation
V. G. Elshina
Irkutsk National Research Technical University
Russian Federation
Russian Federation
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Review
For citations:
Vchislo N.V., Verochkina E.A., Elshina V.G. SYNTHESIS OF 2-METHOXY-3-ARYL(HETARYL)PROPENALS BY ALDOL CONDENSATION UNDER MICROWAVE IRRADIATION. Proceedings of Universities. Applied Chemistry and Biotechnology. 2017;7(4):9-15. (In Russ.) https://doi.org/10.21285/2227-2925-2017-7-4-9-15
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