STUDY OF INTERACTION BETWEEN CHITOSAN AND SOME HYDROLASES
https://doi.org/ 10.21285/2227-2925-2017-7-1-62-71
Abstract
The properties of biopolymers based on chitosan, hydrolytic enzymes and some organic compounds have been studied. Enzymatic activities of obtained materials and their structure were estimated using absorption spectroscopy, dynamic light scattering, and electron microscopy. Also we proposed in this paper the structural scheme of designed materials and interaction mechanisms of system’s components to create the medical materials based on studied therapeutic agents with adjusted properties in future.
About the Authors
E. E. Dosadina
D. Mendeleev University of Chemical Technology
Russian Federation
Russian Federation
M. A. Bikineeva
D. Mendeleev University of Chemical Technology
Russian Federation
Russian Federation
A. Y. Evdokimenko
D. Mendeleev University of Chemical Technology
Russian Federation
Russian Federation
E. E. Savelyeva
D. Mendeleev University of Chemical Technology
Russian Federation
Russian Federation
E. O. Medusheva
Scientific Research Institute of Textile Materials
Russian Federation
Russian Federation
A. A. Belov
D. Mendeleev University of Chemical Technology
Russian Federation
Russian Federation
References
1. Belov A.A. Textile materials containing immobilized hydrolases for medical and cosmetic purposes. Production. Properties. Application. Germany: LAP LAMBERT Acad. Pub., GmbH &Co. KG, 2012. 242 p.
2. Скрябин К.Г., Вихоревая Г.А., Варламов В.П. Хитин и хитозан. Получение, свойства и применение. М.: Наука, 2002. 368 с.
3. Miranda Castro S.P., Lizarraga Paulin E.G. Is Chitosan a New Panacea? Areas of Application // The Complex World of Polysaccharides. Edited by Desiree Nedra Karunaratne. Chapter 1. In Tech, 2012. P. 3-46. DOI: 10.5772/51200
4. Гришин А.А., Зорина Н.В., Луцкий В.И. Хитин и хитозан: химия, биологическая активность, применение // Известия вузов. Прикладная химия и биотехнология. 2014. N 1 (6). С. 29-34.
5. Sato M., Onishi H., Takahara J. Machida Y., Nagai T. In vivo drug release and antitimor characteristics of water-soluble conjugates of mitomycin C with glycol-chitosan and N-succinil-chitosan // Biological and Pharmaceutical Bulletin. 1996. V. 19, N. 9. P. 1170-1177.
6. Dosadina E.E., Kulmetyeva M.A., Belov A.A. The changing of enzymatic activity of hydrolases immobilized on natural polysaccharide matrix for purulent and burn wounds treatment during storing and exploitation. Biointerface Research in Applied Chemistry. V. 6, N 3. 2016. pp.1291-1298.
7. Досадина Э.Э., Кульметьева М.А., Дубовикова О.Э., Евдокименко А.Ю., Савельева Е.Е., Белов А.А. Синтез и исследование свойств комплекса протеиназ, иммобилизованных на полисахаридных носителях для медицинского использования // Бутлеровские сообщения. 2016. Т.46, N. 6. C. 1-10.
8. Руденская Г.Н. Брахиурины - сериновые коллагенолитические ферменты крабов // Биоорганическая химия. 2003. T. 29, N. 2. C.117-128.
9. Rudenskaya G.N., Isaev V.A., Shmoylov A.M., Karabasova M.A., Shvets S.V., Miroshnikov A.I., Brusov A.B. Preparation of proteolytic enzymes from Kamchatka crab Paralithodes camchatica hepatopancreas and their application // App. Biochem. Biotech. 2000. V. 88, N 1-3. P.175-183.
10. Досадина Э.Э., Белов А.А. Возможные механизмы взаимодействия хитозана, целлюлозных носителей и белков протеолитического комплекса из гепатопанкреаса краба // Успехи в химии и химической технологии. 2015. N. 8 (167). C. 82-84.
11. Кульметьева М.А., Белов А.А., Досадина Э.Э., Субчева Е.Н. Влияние хитозана на ферменативную активность протеолитическиого комплекса из гепатопанкреаса краба. // Тр. 15 ежегодной междунар. молодежной конф. «ИБХФ РАН - вузы». М., 2015. C. 83-86.
12. Quijada-Garrido I., Iglesias-Gonzaґlez V., Mazoґn-Arechederra J.M., Barrales-Rienda J.M. The role played by the interactions of small molecules with chitosan and their transition temperatures. Glass-forming liquids: 1,2,3-Propantriol (glycerol) // Carbohydrate Polymers. 2007. V. 68. P. 173-186.
Review
For citations:
Dosadina E.E., Bikineeva M.A., Evdokimenko A.Y., Savelyeva E.E., Medusheva E.O., Belov A.A. STUDY OF INTERACTION BETWEEN CHITOSAN AND SOME HYDROLASES. Proceedings of Universities. Applied Chemistry and Biotechnology. 2017;7(1):62-71. (In Russ.) https://doi.org/ 10.21285/2227-2925-2017-7-1-62-71
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